英文名称 | Crizotinib (PF-02341066) |
---|---|
中文名称 | 克唑替尼 |
CAS号 | 877399-52-5 |
分子式 | C21H22Cl2FN5O |
分子量 | 450.34 |
外观 | White to light brown powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名称 | Crizotinib (PF-02341066) |
---|---|
中文名称 | 克唑替尼 |
CAS号 | 877399-52-5 |
分子式 | C21H22Cl2FN5O |
分子量 | 450.34 |
外观 | White to light brown powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Crizotinib (formerly known as PF-02341066; trade name: Xalkori) is a potent, orally bioavailable small molecule inhibitor of c-Met and ALK that is bioavailable when taken orally. In assays based on cells, it inhibits c-Met and ALK with IC50 values of 11 nM and 24 nM, respectively.