英文名称 | Laduviglusib trihydrochloride | CHIR-99021 Trihydrochloride |
---|---|
中文名称 | CHIR-99021三盐酸盐 | 拉格鲁西布三盐酸盐 |
CAS号 | 1782235-14-6 |
分子式 | C22H18Cl2N8·3HCl |
分子量 | 574.72 |
外观 | White to light yellow powder |
储存条件 | 4°C, sealed storage, away from moisture |
英文名称 | Laduviglusib trihydrochloride | CHIR-99021 Trihydrochloride |
---|---|
中文名称 | CHIR-99021三盐酸盐 | 拉格鲁西布三盐酸盐 |
CAS号 | 1782235-14-6 |
分子式 | C22H18Cl2N8·3HCl |
分子量 | 574.72 |
外观 | White to light yellow powder |
储存条件 | 4°C, sealed storage, away from moisture |
Laduviglusib (CHIR-99021) trihydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib trihydrochloride is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib trihydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib trihydrochloride induces autophagy.