英文名称 | Pramlintide Acetate |
---|---|
中文名称 | 醋酸普兰林肽 |
CAS号 | 196078-30-5 |
分子式 | C171H267N51O53S2 • XC2H4O2 [XH2O] |
分子量 | 3949.39 |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名称 | Pramlintide Acetate |
---|---|
中文名称 | 醋酸普兰林肽 |
CAS号 | 196078-30-5 |
分子式 | C171H267N51O53S2 • XC2H4O2 [XH2O] |
分子量 | 3949.39 |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Pramlintide is a non-amyloidogenic analog of the antidiabetic peptide hormone amylin that contains proline residues substituted at positions 25, 28, and 29. It stimulates cAMP production in HEK293 cells expressing human amylin receptor 1a (AMY1a), AMY2a, and AMY3a (EC50s = 0.35, 22.9, and 0.89 nM, respectively). Pramlintide inhibits human islet amyloid polypeptide fibrilization in a concentration-dependent manner.