英文名称 | Tivantinib | ARQ-197 |
---|---|
中文名称 | (3R,4R) 替凡替尼 (ARQ 197), 肝细胞生长因子受体抑制剂 | 替万替尼 |
CAS号 | 905854-02-6 |
分子式 | C23H19N3O2 |
分子量 | 369.42 |
外观 | Light brown to brown powder |
英文名称 | Tivantinib | ARQ-197 |
---|---|
中文名称 | (3R,4R) 替凡替尼 (ARQ 197), 肝细胞生长因子受体抑制剂 | 替万替尼 |
CAS号 | 905854-02-6 |
分子式 | C23H19N3O2 |
分子量 | 369.42 |
外观 | Light brown to brown powder |
Tivantinib is the first non-ATP-competitive c-Met inhibitor with Ki of 0.355 μM in a cell-free assay, little activity to Ron, and no inhibition to EGFR, InsR, PDGFRα or FGFR1/4. Tivantinib (ARQ 197) induces a G2/M arrest and apoptosis.
PMID: 20484018 DOI: 10.1158/1535-7163.MCT-09-1173