英文名称 | TG101209 |
---|---|
中文名称 | TG101209 |
CAS号 | 936091-14-4 |
分子式 | C26H35N7O2S |
分子量 | 509.67 |
外观 | White to gray powder |
储存条件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
英文名称 | TG101209 |
---|---|
中文名称 | TG101209 |
CAS号 | 936091-14-4 |
分子式 | C26H35N7O2S |
分子量 | 509.67 |
外观 | White to gray powder |
储存条件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM, less potent to Flt3 and RET (c-RET) with IC50 of 25 nM and 17 nM in cell-free assays, ~30-fold selective for JAK2 than JAK3, sensitive to JAK2V617F and MPLW515L/K mutations.
PMID: 17541402 DOI: 10.1038/sj.leu.2404750
A novel zebrafish jak2a(V581F) model shared features of human JAK2(V617F) polycythemia vera
PMID: 19772888 DOI: 10.1016/j.exphem.2009.08.008
Inhibition of JAK2 signaling by TG101209 enhances radiotherapy in lung cancer models.
PMID: 21325979 PMCID: PMC3104103 DOI: 10.1097/JTO.0b013e31820d9d11
PMID: 22384256 PMCID: PMC3288102 DOI: 10.1371/journal.pone.0032451