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PT-2385

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PT-2385

产品编号：CL2835 CAS No.：1672665-49-4 MDLNo： 分子式：C17H12F3NO4S 分子量：383.34

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基本信息

英文名称	PT-2385
中文名称	PT-2385
CAS号	1672665-49-4
分子式	C17H12F3NO4S
分子量	383.34
外观	White to off-white powder
储存条件	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

产品详情

PT2385 is an orally active, small molecule inhibitor of hypoxia inducible factor (HIF)-2alpha, with potential antineoplastic activity. Upon oral administration, HIF-2alpha inhibitor PT2385 allosterically binds to HIF-2alpha, thereby preventing HIF-2alpha heterodimerization and its subsequent binding to DNA. This results in decreased transcription and expression of HIF-2alpha downstream target genes, many of which regulate tumor cell growth and survival.