英文名称 | PT-2385 |
---|---|
中文名称 | PT-2385 |
CAS号 | 1672665-49-4 |
分子式 | C17H12F3NO4S |
分子量 | 383.34 |
外观 | White to off-white powder |
储存条件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
英文名称 | PT-2385 |
---|---|
中文名称 | PT-2385 |
CAS号 | 1672665-49-4 |
分子式 | C17H12F3NO4S |
分子量 | 383.34 |
外观 | White to off-white powder |
储存条件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
PT2385 is an orally active, small molecule inhibitor of hypoxia inducible factor (HIF)-2alpha, with potential antineoplastic activity. Upon oral administration, HIF-2alpha inhibitor PT2385 allosterically binds to HIF-2alpha, thereby preventing HIF-2alpha heterodimerization and its subsequent binding to DNA. This results in decreased transcription and expression of HIF-2alpha downstream target genes, many of which regulate tumor cell growth and survival.