ZYF0033 | HPK1-IN-22

规格	库存	目录价	会员专享价	数量
1 mg	3-5days	￥766.00	登录后可见	- +
5 mg	3-5days	￥1908.00	登录后可见	- +

规格

库存

目录价

会员专享价

数量

1 mg

3-5days

￥766.00

登录后可见

- +

5 mg

3-5days

￥1908.00

登录后可见

- +

基本信息

英文名称	ZYF0033 \| HPK1-IN-22
中文名称	ZYF0033 \| HPK1-IN-22
CAS号	2380300-79-6
分子式	C26H30N4O2S
分子量	462.61
外观	White to off-white powder
储存条件	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

产品详情

HPK1-IN-22 (compound ZYF0033) is a hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 less than 10 nM based on the phosphorylation inhibition of MBP protein. HPK1-IN-22 decreases the phosphorylation of SLP76 (serine 376). HPK1-IN-22 promotes anticancer immune responses.HPK1-IN-22 inhibits tumor growth and caused increases intratumoral infiltration of DCs, NK cells, and CD107a+CD8+ T cells but decreased infiltration of regulatory T cells, PD-1+CD8+ T cells, TIM-3+CD8+ T cells, and LAG3+CD8+ T cells in the 4T-1 syngeneic mouse model.

ZYF0033 | HPK1-IN-22

ZYF0033 | HPK1-IN-22

化学品安全说明书(MSDS)