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BIX-01294

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BIX-01294

产品编号：CL2754 CAS No.：935693-62-2 MDLNo： 分子式：C28H38N6O2 分子量：490.64

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基本信息

英文名称	BIX-01294
中文名称	BIX-01294
CAS号	935693-62-2
分子式	C28H38N6O2
分子量	490.64
外观	White to off-white powder
储存条件	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4℃, long-term (months to years) storage at -20 ℃.

产品详情

BIX-01294 is a reversible and highly selective G9a and GLP Histone Methyltransferase inhibitor, with IC₅₀s of of 1.7 μM and 0.9 μM, respectively. BIX-01294 inhibits G9a/GLP by competing for binding with the amino acids N-terminal of the substrate lysine residue. BIX-01294, a (1H-1,4-diazepin-1-yl)-quinazolin-4-yl amine derivative, induces necroptosis and autophagy. BIX-01294 has antitumor activity in recurrent tumor cells。