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BLU9931

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BLU9931

产品编号：CL2721 CAS No.：1538604-68-0 MDLNo： 分子式：C26H22Cl2N4O3 分子量：509.38

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基本信息

英文名称	BLU9931
中文名称	BLU9931
CAS号	1538604-68-0
分子式	C26H22Cl2N4O3
分子量	509.38
外观	Off-white to light yellow powder
储存条件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

产品详情

BLU9931 is a potent and irreversible small-molecule inhibitor of FGFR4, as a targeted therapy to treat patients with HCC whose tumors have an activated FGFR4 signaling pathway. BLU9931 is exquisitely selective for FGFR4 versus other FGFR family members and all other kinases. BLU9931 shows remarkable antitumor activity in mice bearing an HCC tumor xenograft that overexpresses FGF19 due to amplification as well as a liver tumor xenograft that overexpresses FGF19 mRNA but lacks FGF19 amplification. Approximately one third of patients with HCC whose tumors express FGF19 together with FGFR4 and its coreceptor klotho β (KLB) could potentially respond to treatment with an FGFR4 inhibitor.