英文名称 | Tesirine | SG3249 |
---|---|
中文名称 | 特司林 |
CAS号 | 1595275-62-9 |
分子式 | C75H101N9O23 |
分子量 | 1496.65 |
外观 | White to light yellow powder |
储存条件 | Avoid light, nitrogen, -20 ℃ |
英文名称 | Tesirine | SG3249 |
---|---|
中文名称 | 特司林 |
CAS号 | 1595275-62-9 |
分子式 | C75H101N9O23 |
分子量 | 1496.65 |
外观 | White to light yellow powder |
储存条件 | Avoid light, nitrogen, -20 ℃ |
Tesirine (SG-3249; SG3249), cathepsin B-cleavable valine-alanine pyrrolobenzodiazepine (PBD) dimer used as an antibody-drug conjugate (ADC) payload; Tesirine was designed to combine the potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. Rovalpituzumab tesirine is a first-in-class ADC directed against delta-like protein 3 (DLL3), a novel target identified in tumour-initiating cells and expressed in small-cell lung cancer.
PMID: 29992976 PMCID: PMC6041317 DOI: 10.1038/s41598-018-28533-4