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奥利司他

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Orlistat

产品编号：CL2557 CAS No.：96829-58-2 MDLNo： 分子式：C29H53NO5 分子量：495.73

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规格	库存	目录价	会员专享价	数量
5 g	3-5days	￥200.00	登录后可见	- +
10 g	3-5days	￥300.00	登录后可见	- +
25 g	3-5days	￥500.00	登录后可见	- +

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基本信息

英文名称	Orlistat
中文名称	奥利司他
CAS号	96829-58-2
分子式	C29H53NO5
分子量	495.73
外观	White to off-white powder
储存条件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

产品详情

Orlistat (also known as tetrahydrolipstatin, or Ro 18-0647, Lipase Inhibitor, THL ) is a potent and general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice. Orlistat is a drug designed to treat obesity. Orlistat is the saturated derivative of lipstatin, a potent natural inhibitor of pancreatic lipases isolated from the bacterium Streptomyces toxytricini. Mechanistic studies suggest that Orlistat inhibits the thioesterase domain of fatty acid synthase (FAS) and as a result halts cell proliferation and causes cell apoptosis. More detailed experiments show that gradually Orlistat affects the retinoblastoma protein pathway and leads to cell-cycle arrest at G1/S boundary.