Olverembatinib (GZD824; HQP1351)

规格	库存	目录价	会员专享价	数量
10 mg	3-5days	￥650.00	登录后可见	- +
25 mg	3-5days	￥980.00	登录后可见	- +
50 mg	3-5days	￥1460.00	登录后可见	- +

规格

库存

目录价

会员专享价

数量

10 mg

3-5days

￥650.00

登录后可见

- +

25 mg

3-5days

￥980.00

登录后可见

- +

50 mg

3-5days

￥1460.00

登录后可见

- +

基本信息

英文名称	Olverembatinib (GZD824; HQP1351)
中文名称	4-甲基-N-[4-[(4-甲基-1-哌嗪基)甲基]-3-(三氟甲基)苯基]-3-[2-(1H-吡唑并[3,4-b]吡啶-5-基)乙炔基]苯甲酰胺/耐克替尼
CAS号	1257628-77-5
分子式	C29H27F3N6O
分子量	532.56
外观	Off-white to yellow powder
储存条件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

产品详情

GZD824 potently suppressed proliferation of Bcr-Abl-positive K562 and Ku812 human CML cells with IC(50) values of 0.2 and 0.13 nM, respectively. It also displayed good oral bioavailability (48.7%), a reasonable half-life (10.6 h), and promising in vivo antitumor efficacy.

GZD824 induced tumor regression in mouse xenograft tumor models driven by Bcr-Abl(WT) or the mutants and significantly improved the survival of mice bearing an allograft leukemia model with Ba/F3 cells harboring Bcr-Abl(T315I).

4-甲基-N-[4-[(4-甲基-1-哌嗪基)甲基]-3-(三氟甲基)苯基]-3-[2-(1H-吡唑并[3,4-b]吡啶-5-基)乙炔基]苯甲酰胺/耐克替尼

Olverembatinib (GZD824; HQP1351)

化学品安全说明书(MSDS)