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PD184352(CI-1040)

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PD184352(CI-1040)

产品编号：CL2485 CAS No.：212631-79-3 MDLNo： 分子式：C17H14ClF2 IN2O2 分子量：478.66

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规格	库存	目录价	会员专享价	数量
5 mg	3-5days	￥400.00	登录后可见	- +
10 mg	3-5days	￥650.00	登录后可见	- +
25 mg	3-5days	￥1160.00	登录后可见	- +

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基本信息

英文名称	PD184352(CI-1040)
中文名称	PD184352(CI-1040)
CAS号	212631-79-3
分子式	C17H14ClF2 IN2O2
分子量	478.66
外观	White to off-white powder
储存条件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

产品详情

PD184352 (PD-184352; CI-1040), an analog of benzhydroxamate, is an orally bioactive, specific, allosteric/non-ATP competitive MEK1/2 inhibitor with potential anticancer activity. In cell-based assays, it inhibits MEK1/2 with IC50 values of 17 nM and exhibits a 100-fold preference for MEK1/2 over MEK5. In mouse xenograft models, it exhibits strong in vitro anti-proliferative activity and significant in vivo antitumor efficacy.