首页 > 产品目录 > 信号通路 > TGF-beta/Smad | 信号通路 > PKC (蛋白激酶C) > Go 6983

Go 6983

ChemLeader 98+%

Go 6983

产品编号：CL2440 CAS No.：133053-19-7 MDLNo： 分子式：C26H26N4O3 分子量：442.51

加入收藏分享给朋友

规格	库存	目录价	会员专享价	数量
5 mg	In-stock	￥600.00	登录后可见	- +
10 mg	In-stock	￥900.00	登录后可见	- +
25 mg	3-5days	￥1575.00	登录后可见	- +

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

下载COA

发送询价加入购物车

基本信息
相关文档
产品详情
相关文献

基本信息

英文名称	Go 6983
中文名称	Go 6983
CAS号	133053-19-7
分子式	C26H26N4O3
分子量	442.51
外观	Pink to red powder
储存条件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

产品详情

Go 6983 (also known as GOE-6983; Go-6983; GOE6983; Go6983) is a novel and potent pan-PKC (protein kinase C) inhibitor with potential anticancer and cardioprotective activity. It inhibits PKCα, PKCβ, PKCγ and PKCδ with IC50s of 7 nM, 7 nM, 6 nM and 10 nM, respectively. Go 6983 shows less potency against PKCζ and is inactive on PKCμ. GO6893 displays cardioprotective properties and can reduce polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury. When tested with MCF-7 and T47D cells, Go 6983 showed reversible effect on the down-regulation of PKCαand PKCδ induced by PKC activator PDBu, while decreased the expression of PKCη which up-regulated by PDBu.