英文名称 | Veliparib dihydrochloride (ABT-888 dihydrochloride) |
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中文名称 | 维利帕尼二盐酸盐 |
CAS号 | 912445-05-7 |
分子式 | C13H18Cl2N4O |
分子量 | 317.21 |
外观 | White to off-white powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名称 | Veliparib dihydrochloride (ABT-888 dihydrochloride) |
---|---|
中文名称 | 维利帕尼二盐酸盐 |
CAS号 | 912445-05-7 |
分子式 | C13H18Cl2N4O |
分子量 | 317.21 |
外观 | White to off-white powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Veliparib, also known as ABT-888, is a potent and selective Poly (ADP-Ribose) Polymerase (PARP) Inhibitor. Veliparib enhances apoptosis and autophagy in response to treatments that cause DNA breaks, including radiation and DNA alkylation. ABT-888 is an orally bioavailable inhibitor of PARP1 and PARP2 (Kis = 5.2 and 2.9 nM, respectively).