英文名称 | Bosutinib(SKI-606) |
---|---|
中文名称 | 伯舒替尼 |
CAS号 | 380843-75-4 |
分子式 | C26H29Cl2N5O3 |
分子量 | 530.45 |
外观 | White to light yellow powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名称 | Bosutinib(SKI-606) |
---|---|
中文名称 | 伯舒替尼 |
CAS号 | 380843-75-4 |
分子式 | C26H29Cl2N5O3 |
分子量 | 530.45 |
外观 | White to light yellow powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Bosutinib is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays, respectively. Bosutinib also effectively decreases the activity of PI3K/AKT/mTOR, MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK, p-S6, and p-STAT3. Bosutinib promotes autophagy