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BPTES

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BPTES

产品编号：CL1972 CAS No.：314045-39-1 MDLNo： 分子式：C24H24N6O2S3 分子量：524.68

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规格	库存	目录价	会员专享价	数量
5 mg	In-stock	￥250.00	登录后可见	- +
10 mg	In-stock	￥400.00	登录后可见	- +
25 mg	In-stock	￥600.00	登录后可见	- +
50 mg	In-stock	￥1200.00	登录后可见	- +
100 mg	In-stock	￥1800.00	登录后可见	- +

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基本信息

英文名称	BPTES
中文名称	BPTES
CAS号	314045-39-1
分子式	C24H24N6O2S3
分子量	524.68
外观	White powder
储存条件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

产品详情

BPTES is an allosteric inhibitor of kidney-type glutaminase 1 (GLS1; IC50 = 3.3 μM) that drives the formation of inactive GLS1 tetramers. It is selective for GLS1 over GLS2, glutamate dehydrogenase, and γ-glutamyl transpeptidase. BPTES decreases glutaminase activity and reduces proliferation of aerobic P493 cells as well as induces cell death, increases the production of reactive oxygen species (ROS), and reduces ATP levels in hypoxic P493 cells. It also decreases ATP-linked and uncoupled oxygen consumption in C2C12 myotubes when used in combination with UK 5099 and/or etomoxir. In vivo, BPTES (12.5 mg/kg) reduces tumor volume in a P493 lymphoma mouse xenograft model.