英文名称 | LY2109761 |
---|---|
中文名称 | LY2109761 |
CAS号 | 700874-71-1 |
分子式 | C26H27N5O2 |
分子量 | 441.52 |
外观 | White to yellow powder |
储存条件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
英文名称 | LY2109761 |
---|---|
中文名称 | LY2109761 |
CAS号 | 700874-71-1 |
分子式 | C26H27N5O2 |
分子量 | 441.52 |
外观 | White to yellow powder |
储存条件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM in a cell-free assay, respectively; shown to negatively affect the phosphorylation of Smad2. LY2109761 blocks autophagy and induces apoptosis.