Fedratinib | TG-101348

规格	库存	目录价	会员专享价	数量
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规格

库存

目录价

会员专享价

数量

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基本信息

英文名称	Fedratinib \| TG-101348 \| SAR 302503
中文名称	菲卓替尼
CAS号	936091-26-8
分子式	C27H36N6O3S
分子量	524.68
外观	White to light yellow powder
储存条件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

产品详情

Fedratinib, also known as TG101348 and SAR302503, is a JAK2 inhibitor, is also an orally bioavailable, small-molecule, ATP-competitive inhibitor of Janus-associated kinase 2 (JAK2) with potential antineoplastic activity. JAK2 inhibitor TG101348 competes with JAK2 as well as the mutated form AK2V617F for ATP binding, which may result in inhibition of JAK2 activation, inhibition of the JAK-STAT signaling pathway, and the induction of tumor cell apoptosis. JAK2 is the most common mutated gene in bcr-abl-negative myeloproliferative disorders (MPDs); the mutated form JAK2V617F has a valine-to-phenylalanine modification at position 617 and plays a key role in tumor cell proliferation and survival.

菲卓替尼

Fedratinib | TG-101348 | SAR 302503

化学品安全说明书(MSDS)