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格列喹酮

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Gliquidone

产品编号：CL1154 CAS No.：33342-05-1 MDLNo： 分子式：C27H33N3O6S 分子量：527.63

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规格	库存	目录价	会员专享价	数量
250 mg	In-stock	￥150.00	登录后可见	- +
500 mg	In-stock	￥200.00	登录后可见	- +
1 g	In-stock	￥300.00	登录后可见	- +

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基本信息

英文名称	Gliquidone
中文名称	格列喹酮
CAS号	33342-05-1
分子式	C27H33N3O6S
分子量	527.63
外观	White crystalline powder odorless

产品详情

Gliquidone (Glurenorm,AR-DF 26) is an ATP-sensitive K⁺ channel antagonist with IC50 of 27.2 nM.

Gliquidone is a second generation sulfonylurea that selectively inhibits ATP-sensitive potassium channel currents (IKATP) in pancreatic β-cells (IC50s = 0.45, 119.1, and 149.7 µM for HIT-T15 cells, cardiomyocytes, and vascular smooth muscle cells, respectively). It is also a peroxisome proliferator-activated receptor γ (PPARγ) agonist (EC50 = 10 μM in a transactivation assay). Gliquidone (0.2 nmol/g) decreases plasma levels of D-glucose and stimulates insulin release in anesthetized rats. It decreases blood glucose levels, serum alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) activities, and hepatic lipid peroxidation and increases hepatic glutathione (GSH) levels in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104) when administered at a dose of 10 mg/kg.