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达格列净

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Dapagliflozin (BMS-512148)

产品编号:CL1127 CAS No.:461432-26-8 MDLNo: 分子式:C21H25ClO6 分子量:408.87
规格 库存 目录价 会员专享价 数量
500 mg In-stock ¥488.00 登录后可见
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1 g 3-5days ¥788.00 登录后可见
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基本信息
英文名称 Dapagliflozin (BMS-512148)
中文名称达格列净
CAS号461432-26-8
分子式C21H25ClO6
分子量408.87
外观White to off-white powder
储存条件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
产品详情

Dapagliflozin (formerly known as BMS-512148; trade names Farxiga in the US and Forxiga in the EU) is a potent and selective hSGLT2 (sodium-glucose transport proteins) inhibitor with anti-diabetic activity. It inhibits hSGLT2 with an EC50 of 1.1 nM, and exhibits1200-fold selectivity over hSGLT1.  Dapagliflozin inhibits subtype 2 of the sodium-glucose transport proteins (SGLT2) which are responsible for at least 90% of the glucose reabsorption in the kidney. Urine is the means by which blood glucose is expelled when this transporter mechanism is blocked.

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