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AOH1996/N-[2-[2-(3-methoxyphenoxy)anilino]-2-oxoethyl]naphthalene-1-carboxamide

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AOH1996/N-[2-[2-(3-methoxyphenoxy)anilino]-2-oxoethyl]naphthalene-1-carboxamide

产品编号:CL1093 CAS No.:2089314-64-5 MDLNo: 分子式:C26H22N2O4 分子量:426.46
规格 库存 目录价 会员专享价 数量
5 mg In-stock ¥1000.00 登录后可见
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10 mg In-stock ¥1600.00 登录后可见
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25 mg In-stock ¥2800.00 登录后可见
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50 mg In-stock ¥4500.00 登录后可见
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100 mg In-stock ¥6800.00 登录后可见
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基本信息
英文名称 AOH1996/N-[2-[2-(3-methoxyphenoxy)anilino]-2-oxoethyl]naphthalene-1-carboxamide
中文名称AOH1996/N-[2-[2-(3-methoxyphenoxy)anilino]-2-oxoethyl]naphthalene-1-carboxamide
CAS号2089314-64-5
分子式C26H22N2O4
分子量426.46
外观White powder
产品详情

AOH1996 is an inhibitor of proliferating cell nuclear antigen (PCNA).It binds to PCNA in a thermal shift assay. AOH1996 (500 nM) induces apoptosis in SK-N-DZ neuroblastoma cells but not 7SMOO32 normal neural crest stem cells. It induces DNA damage in SK-N-AS neuroblastoma cells expressing wild-type DNA-directed RNA polymerase II subunit RPB1 but not in SK-N-AS cells expressing RPB1Y418A. AOH1996 (40 mg/kg) decreases tumor volume in SK-N-BE(2)-C neuroblastoma, MDA-MB-468 breast cancer, and NCI H82 small cell lung cancer mouse xenograft models.

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