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SB-431542

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SB-431542

产品编号：CL1082 CAS No.：301836-41-9 MDLNo： 分子式：C22H16N4O3 分子量：384.39

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规格	库存	目录价	会员专享价	数量
10 mg	In-stock	￥350.00	登录后可见	- +
20 mg	In-stock	￥600.00	登录后可见	- +
50 mg	In-stock	￥1150.00	登录后可见	- +

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基本信息

英文名称	SB-431542
中文名称	SB-431542
CAS号	301836-41-9
分子式	C22H16N4O3
分子量	384.39
外观	white to off-white solid powder
储存条件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

产品详情

SB-431542 is a novel small molecule inhibitor of the type I TGF-beta receptor, on a panel of human malignant glioma cell lines. SB-431542 blocked the phosphorylation and nuclear translocation of the SMADs, intracellular mediators of TGF-beta signaling, with decreased TGF-beta-mediated transcription. Furthermore, SB-431542 inhibited the expression of two critical effectors of TGF-beta-vascular endothelial growth factor and plasminogen activator inhibitor-1.