英文名称 | Docetaxel Anhydrous |
---|---|
中文名称 | 无水多西他赛 |
CAS号 | 114977-28-5 |
分子式 | C43H53NO14 |
分子量 | 807.88 |
外观 | White or almost white, crystalline, hygroscopic powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名称 | Docetaxel Anhydrous |
---|---|
中文名称 | 无水多西他赛 |
CAS号 | 114977-28-5 |
分子式 | C43H53NO14 |
分子量 | 807.88 |
外观 | White or almost white, crystalline, hygroscopic powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
Docetaxel is a microtubule-stabilizing agent and a semisynthetic derivative of paclitaxel.It promotes microtubule assembly in a cell-free assay when used at a concentration of 20 µM and is cytotoxic to J774.2 cells (EC50 = 0.05 µM).In vivo, docetaxel inhibits tumor growth in several cancer models, including B16 murine melanoma and P388 murine leukemia models. Formulations containing docetaxel have been used in the treatment of head and neck, breast, and non-small cell lung cancer, gastric adenocarcinoma, and castration-resistant prostate cance