首页 > 产品目录 > 信号通路 > Protein Tyrosine Kinase/RTK > VEGFR > 尼达尼布乙磺酸盐

尼达尼布乙磺酸盐

ChemLeader 98+%

Nintedanib Ethanesulfonate Salt

产品编号：CL1034A CAS No.：656247-18-6 MDLNo： 分子式：C31H33N5O4.C2H6O3S 分子量：649.76

加入收藏分享给朋友

规格	库存	目录价	会员专享价	数量
10 mg	In-stock	￥300.00	登录后可见	- +
25 mg	In-stock	￥500.00	登录后可见	- +
50 mg	In-stock	￥900.00	登录后可见	- +
100 mg	In-stock	￥1300.00	登录后可见	- +

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

下载COA

发送询价加入购物车

基本信息
相关文档
产品详情
相关文献

基本信息

英文名称	Nintedanib Ethanesulfonate Salt
中文名称	尼达尼布乙磺酸盐
CAS号	656247-18-6
分子式	C31H33N5O4.C2H6O3S
分子量	649.76
外观	Yellow solid

产品详情

BIBF 1120 is an inhibitor of the receptor tyrosine kinases VEGFR, FGFR, and PDGFR (IC50s = 13-34, 37-610, 59, and 65 nM for VEGFR1-3, FGFR1-4, PDGFRα, and PDGFRβ, respectively).1 It is selective for VEGFR, FGFR, and PDGFR over a panel of 33 kinases but does inhibit FLT3, LCK, LYN, and Src (IC50s = 16-156 nM). BIBF 1120 inhibits growth factor-dependent proliferation of human umbilical vascular endothelial cells (HUVECs), human microvascular skin endothelial cells (HSMECs), human umbilical artery smooth muscle cells (HUASMCs), and bovine retinal pericytes (BRPs; EC50s = 7-290 nM). In vivo, BIBF 1120 (100 mg/kg) reduces tumor microvessel density and the number of PDGFRβ-expressing perivascular cells in a FaDu head and neck small cell carcinoma mouse xenograft model. It also inhibits tumor growth in a Caki-1 renal cancer mouse xenograft model. Formulations containing BIBF 1120 have been used in the treatment of idiopathic pulmonary fibrosis and non-small cell lung cancer (NSCLC).