首页 > 产品目录 > 信号通路 > Stem Cells & Wnt | 干细胞及 Wnt 通路 > ROCK > 反式-4-[(R)-1-氨基乙基]-N-(4-吡啶基)环己烷甲酰胺二盐酸盐

反式-4-[(R)-1-氨基乙基]-N-(4-吡啶基)环己烷甲酰胺二盐酸盐

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Y-27632 Dihydrochloride; Y-27632 2HCl

产品编号:CL1003 CAS No.:129830-38-2 MDLNo: 分子式:C14H21N3O.2HCl 分子量:320.26
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5 mg In-stock ¥650.00 登录后可见
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25 mg In-stock ¥1600.00 登录后可见
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50 mg In-stock ¥2800.00 登录后可见
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250 mg In-stock ¥4500.00 登录后可见
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基本信息
英文名称 Y-27632 Dihydrochloride; Y-27632 2HCl
中文名称反式-4-[(R)-1-氨基乙基]-N-(4-吡啶基)环己烷甲酰胺二盐酸盐
CAS号129830-38-2
分子式C14H21N3O.2HCl
分子量320.26
外观White to off-white solid powder
产品详情

The ROCK family of Rho-associated serine-threonine protein kinases is known to play an important role in Rho-mediated cell adhesion and smooth muscle contraction. Y-27632 is a potent, ATP-competitive inhibitor of ROCKs including p160ROCK (Ki = 140 nM) and ROCK2 (IC50 = 800 nM). It also inhibits PRK2 with an IC50 value of 600 nM. One-hour treatment with 10 µM Y-27632 blocks apoptosis of dissociated cultured human embryonic stem cells, increasing cloning efficiency by 25% and sustaining survival up to 30 passages. 

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