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盐酸多柔比星,盐酸阿霉素

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Doxorubicin(Adriamycin) Hydrochloride

产品编号：CL1004 CAS No.：25316-40-9 MDLNo： 分子式：C27H29NO11.HCl 分子量： 579.98

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规格	库存	目录价	会员专享价	数量
100 mg	In-stock	￥260.00	登录后可见	- +
500 mg	In-stock	￥750.00	登录后可见	- +
1 g	In-stock	￥1260.00	登录后可见	- +

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基本信息

英文名称	Doxorubicin(Adriamycin) Hydrochloride
中文名称	盐酸多柔比星,盐酸阿霉素
CAS号	25316-40-9
分子式	C27H29NO11.HCl
分子量	579.98
外观	Orange red powder
储存条件	Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).

产品详情

Doxorubicin is an anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids; the formation of oxygen free radicals also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular effects.